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Nutrigenetics (DNA-Based Diet and Nutrition) can be used to modify existing standard guidelines and provide an element of personalization to the otherwise “one size fits all” advice. It can be beneficial when it is added to other information such as gender, height, weight, age, state of health etc., it is not used in isolation nor does it override other parameters. Nutrigenetics is part of everyday nutrition – it is not specifically therapeutic and does not depend on the use of nutraceuticals or supplements.
In general use, it is not intended for specific disease prevention but as an aid in optimizing diet and lifestyle for promoting long term health based on the best evidence that is available. Nutrigenetic, and indeed nutritional advice in general, is useful for maintaining health and its primary purpose is not for treating disease.
These points are all important for determining the threshold of evidence required to support nutrigenetic advice and in this context the appropriate level of evidence should be the same as that applied to existing nutritional guidelines in the first place. This is the case for several gene x diet interactions and there is evidence that nutrigenetic advice is better understood and more likely to be followed compared to general dietary advice plus it can be beneficial for example in long-term weight control.
Nutrigenetics represents right now a valuable tool in the hands of the individual and the health professional, especially for dieticians and nutritionists who should incorporate evidence-based gene/diet information when devising nutrition programs for their clients. Health professionals routinely evaluate a range of biological data (biomarkers, height, weight, gender, ethnicity, health issues, etc.) when formulating personalized diets and it is entirely logical that genotype should also be included where the evidence is sufficient.
Nutrigenetics involves the study of how individual genetic variation affects interaction with components of the diets, including micro & macronutrients and toxins. Genetic variation has been demonstrated to affect uptake, transport, metabolism and elimination of food components and also affects individual daily requirements for some essential nutrients. Indeed, there has been good evidence available for at almost 20 years that: “With the identification of polymorphisms, or common mutations, in vitamin metabolism, large percentages of the population may have higher requirements for specific vitamins” -Prof. Rima Rozen, Am. J. Clin. Nutr. 76(2), 301–2 (2002)
Healthy eating is not a straight forward proposition in the modern world, and expert committees charged with the responsibility of making dietary recommendations have to do so in the context of complex and incomplete information. The goal of personalized nutrition is not to substitute the official guidelines but to enhance or modify them for the individual where there is available evidence to do so. The level of evidence for nutrigenetic advice should be assessed according to the same standards as traditional nutritional advice.
Test your DNA for a selection of key genes to help you truly understand your genetic response to training.
• Diet Type Recommendation
• Carbohydrate Response
• Saturated Fat Response
• Lactose Intolerance
• Gluten Intolerance
• Detoxification Profile
• Anti-Oxidant Need
• Omega-3 Need
• Vitamin B Need
• Vitamin D Need
• Alcohol Sensitivity
• Salt Sensitivity
• Caffeine Sensitivity
• And more…
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Nutrigenomics is a branch of nutritional genomics and is the study of the effects of foods and food constituents on gene expression. This means that nutrigenomics is research focusing on identifying and understanding molecular-level interaction between nutrients and other dietary bioactives with the genome. Nutrigenomics has also been described by the influence of genetic variation on nutrition, by correlating gene expression or SNPs with a nutrient’s absorption, metabolism, elimination or biological effects. By doing so, nutrigenomics aims to develop rational means to optimise nutrition with respect to the subject’s genotype.
By determining the mechanism of the effects of nutrients or the effects of a nutritional regime, nutrigenomics tries to define the causality|relationship between these specific nutrients and specific nutrient regimes (diets) on human health. Nutrigenomics has been associated with the idea of personalized nutrition based on genotype. While there is hope that nutrigenomics will ultimately enable such personalised dietary advice, it is a science still in its infancy and its contribution to public health over the next decade is thought to be major. Whilst nutrigenomics is aimed at developing an understanding of how the whole body responds to a food via systems biology, research into the effect of a single gene/single food compound relationships is known as nutrigenetics.
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WeHeal is very grateful to our valued sources of information which include Wikipedia, WebMD, ClinicalTrials.gov, Cancer.gov, Infoplease, and the US CDC (Center for Disease Control).