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For more information, see: Mayo Clinic | Wikipedia
This connective tissue disorder and autoimmune disease causes changes in the skin, blood vessels, internal organs and muscles, and can occur solely on the skin level or internally throughout the entire body. Once diagnosed, symptoms usually progress slowly over time and most often lead to skin darkening, thickening and hardening, causing a tight, mask-like appearance, especially on the face. When this disease spreads to the internal organs like the heart, kidney, lungs and GI tract, the organs begin to fail, leading to complications like lung problems, cancer and heart failure. The cause of this disease is unknown and there are also no methods of prevention, so the mortality rate for those with advanced stages of the disease is high.
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For more information, see: Mayo Clinic | Wikipedia
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