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raineealexis posted an update in the group Alzheimer’s Disease Advocate Network
Synergistic interaction between APOE and family history of Alzheimer’s disease on cerebral amyloid deposition and glucose metabolism | Alzheimer's Research & Therapy | Full TextRecently, the field of gene-gene or gene-environment interaction research appears to have gained growing interest, although it is seldom investigated in Alzheimer’s disease (AD). Hence, the current study aims to investigate interaction effects of the key genetic and environmental risks—the apolipoprotein ε4 allele (APOE4) and family history of late-onset AD (FH)—on AD-related brain changes in cognitively normal (CN) middle-aged and older adults. [11C] Pittsburg compound-B (PiB) positron emission tomography (PET) imaging as well as [18F] fluoro-2-deoxyglucose (FDG) PET that were simultaneously taken with T1-weighted magnetic resonance imaging (MRI) were obtained from 268 CNs from the Korean Brain Aging Study for Early Diagnosis and Prediction of AD (KBASE). Composite standardized uptake value ratios were obtained from PiB-PET and FDG-PET images in the AD signature regions of interests (ROIs) and analyzed. Voxel-wise analyses were also performed to examine detailed regional changes not captured by the ROI analyses. A significant synergistic interaction effect was found between the APOE4 and FH on amyloid-beta (Aβ) deposition in the AD signature ROIs as well as other regions. Synergistic interaction effects on cerebral glucose metabolism were observed in the regions not captured by the AD signature ROIs, particularly in the medial temporal regions. Strong synergistic effects of APOE4 and FH on Aβ deposition and cerebral glucose metabolism in CN adults indicate possible gene-to-gene or gene-to-environment interactions that are crucial for pathogenesis of AD involving Aβ. Other unspecified risk factors—genes and/or environmental—that are captured by the positive FH status might either coexpress or interact with APOE4 to alter AD-related brain changes in CN. Healthy people with both FH and APOE4 need more attention for AD prevention.
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Jakkie joined the group Alzheimer’s Disease Advocate Network
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Jerbear joined the group Alzheimer’s Disease Advocate Network
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Eric Drew posted an update in the group Alzheimer’s Disease Advocate Network
How two experimental Alzheimer's drugs reverse agingNew research in mice reveals the molecular and genetic mechanisms through which two Alzheimer’s drug candidates can reverse aging in general. -
Eric Drew posted an update in the group Alzheimer’s Disease Advocate Network
Good resource for finding memory care facilities!
Find Memory Care Options Near YouAbout seven in 10 adults over 65 will require long-term care at some point in their lives, according to the U.S. Department of Health and Human Services. And according to some estimates, close to 68 percent of older adults in residential care or nursing homes have some degree of cognitive impairment. That means that their … -
Daniel Christian Patient Advocate joined the group Alzheimer’s Disease Advocate Network
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Stronger2gether joined the group Alzheimer’s Disease Advocate Network
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Klarogirl13 joined the group Alzheimer’s Disease Advocate Network
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Liza posted an update in the group Alzheimer’s Disease Advocate Network
Hi everyone. Does anybody know if this blood test to see if someone has Alzheimer’s work? If so, does anyone know where to get the test? I live in San Jose CA. Thanks!
Blood test could detect Alzheimer's up to 16 years before symptoms begin – CNNThe new test looks at a protein found in the blood, that shows brain damage. An increase of this protein indicates brain damage, even before any other symptoms appear.-
Hey Liza! From other literature I read, it seems this blood screening test is still being tested to see how well it correlates with the many types of AD but at this time can not replace current screening methods.
Sorry I don’t have a better resource, the study of AD is in real need of answers!
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Thank you so much for your reply. It explains why I haven’t found any place that does the test 🙂 Have a great day!
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Liza joined the group Alzheimer’s Disease Advocate Network
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raineealexis posted an update in the group Alzheimer’s Disease Advocate Network
Alzheimer's vaccine aims to cut dementia in half, may see human trialsA study outlines advances in research that could lead to a successful vaccine for Alzheimer’s, a fatal brain disease. Trials in animals may pave the way for human trials, according to researchers.-
Thank you Rainee for posting this! This is very exciting news and something that every family with Alzheimer’s in their history should follow!
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