Activity

New research shows that B12 inhibits key enzyme activity in Parkinson’s Disease (LRRK2). Though this research is limited to cellular and animal models at this point, as Iban Ubarretxena pointed out this, “constitutes a huge step forward because it is a neuroprotective vitamin in animal models and has a mechanism unlike that of currently existing inhibitors. So it could be used as a basis to develop new therapies to combat hereditary Parkinson’s associated with pathogenic variants of the LRRK2 enzyme”.

Vitamin B12 Inhibits Key Enzyme in Parkinson’s Disease | Technology Networks

https://www.technologynetworks.com/proteomics/news/vitamin-b12-inhibits-key-enzyme-in-parkinsons-disease-317725

Although most cases of Parkinson’s are sporadic, the inheritable variants of the disease are mainly associated with mutations of the gene that encodes the LRRK2 enzyme. Inhibitors of LRRK2 do exist, however they have many undesirable side effects. Vitamin B12, according to a new study, inhibits the kinase activity of LRRK2 and thus presents as a novel class of modulator for the enzyme.

Quick Research on Lewy Body Dementia

I did find a new clinical trial announcement at the Pacific Neuroscience Institute in LA area here – https://www.pacificneuroscienceinstitute.org/wp-content/uploads/EIP-Flyer-16-Sep-19.pdf . It is double blind, but usually after the trial period they will allow all patients ot get the medication.

Also there are some great resources and you can schedule consultations online here – https://www.pacificneuroscienceinstitute.org/brain-health/conditions-treatment/dementia/lewy-body-dementia/

Unfortunately DLB (Dementia Lewy Body) symptoms include hallucinations and delusions which get worse as disease progresses. This is a drug that treats the hallucinations and delusions – https://www.nuplazid.com/about-parkinsons-disease

NIH Resources – https://www.nia.nih.gov/health/what-lewy-body-dementia

Mayo Clinic – https://www.mayoclinic.org/diseases-conditions/lewy-body-dementia/symptoms-causes/syc-20352025

Foundations and Support – https://www.apdaparkinson.org/article/understanding-parkinsons-disease-dementia-lewy-bodies/

The Difference Between Lewy Body Dementia, Parkinson’s Disease and Alzheimer’s Disease

Clinical Trial Options – https://clinicaltrials.gov/ct2/results?cond=DLB+&term=Lewy+Body+Dementia&cntry=&state=&city=&dist=

I only found a few Interventional (treatment based) Study that I found that was recruiting is in Nashville – https://clinicaltrials.gov/ct2/show/NCT04246437?term=Lewy+Body+Dementia&cond=DLB&draw=7&rank=53

Here is a stem cell treatment study in Connecticut and Florida, but I would definitely contact the lead doctor Steven Levy, MD 203-423-9494 stevenlevy@mdstemcells.com
https://clinicaltrials.gov/ct2/show/NCT03724136?term=Lewy+Body+Dementia&cond=DLB&draw=8&rank=70

For Lewy Body Parkinsoons – https://www.pacificneuroscienceinstitute.org/wp-content/uploads/EIP-Flyer-16-Sep-19.pdf

New research shows that B12 inhibits key enzyme activity in Parkinson’s Disease (LRRK2). Though this research is limited to cellular and animal models at this point, as Iban Ubarretxena pointed out this, “constitutes a huge step forward because it is a neuroprotective vitamin in animal models and has a mechanism unlike that of currently existing inhibitors. So it could be used as a basis to develop new therapies to combat hereditary Parkinson’s associated with pathogenic variants of the LRRK2 enzyme”.

Vitamin B12 Inhibits Key Enzyme in Parkinson’s Disease | Technology Networks

https://www.technologynetworks.com/proteomics/news/vitamin-b12-inhibits-key-enzyme-in-parkinsons-disease-317725

Although most cases of Parkinson’s are sporadic, the inheritable variants of the disease are mainly associated with mutations of the gene that encodes the LRRK2 enzyme. Inhibitors of LRRK2 do exist, however they have many undesirable side effects. Vitamin B12, according to a new study, inhibits the kinase activity of LRRK2 and thus presents as a novel class of modulator for the enzyme.

Parkinsonism is a generic descriptive term that refers to the whole category of neurological diseases that causes slowness of movement. The category includes the classic Parkinson’s disease, many atypical variants, sometimes called “Parkinson’s Plus Syndromes”. The following are two links for care and support. CareXc has a parkinson’s in-home care plan and Brain Support Network has a lot of recent development news.