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Daniel Christian Patient Advocate joined the group Non-Hodgkin’s Lymphoma Advocate Network
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Daniel Christian Patient Advocate joined the group General Cancer Advocate Network
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Daniel Christian Patient Advocate joined the group General Cancer Advocate Network
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Eric Drew posted an update in the group Ovarian Cancer Advocate Network
This is a recent treatment consultation we arranged for a stage 4 ovarian cancer patient. Bottom line, the latest most effective treatments seem to be a combination of immune therapy with a PARP inhibitor therapy. https://en.wikipedia.org/wiki/PARP_inhibitor – Get your free consultation on the WeHeal home page to find the most advanced treatments available for your case.
From your Caris reports, I see that your tumors are PD-L1 positive. It would make sense to try checkpoint immune inhibitors if you haven’t already had them.
Single-agent immunotherapy such as nivolumab (anti-PD-1) has demonstrated a modest response rate of 15% in PD-L1–positive platinum-resistant ovarian cancer. Recently, results of KEYNOTE-100 (NCT02674061) study showed that the overall response rate (ORR) with pembrolizumab (anti-PD-1) in patients with advanced recurrent ovarian cancer was 9% and was higher in patients with PD-L1 expression: 14% with a combined positive score ≥1 and 25% with a composite positive score of ≥10.
Since you also carry the BRCA1 mutation, it would also make sense to investigate PARP inhibitors in combination with immunotherapy. For example, Niraparib (a PARP inhibitor), has shown efficacy in patients with platinum-resistant/refractory ovarian cancer when in combination with pembrolizumab (anti-PD-1). Data from the recurrent ovarian cancer cohort of a recent trial showed an objective response rate of 25% in the 60 evaluable patients. The combination was also well-tolerated by patients. Please see: https://www.onclive.com/conference-coverage/sgo-2018/pembrolizumab-plus-niraparib-shows-promise-in-ovarian-cancer
Additionally, findings from the phase II MEDIOLA trial evaluating the combination of the PARP inhibitor olaparib and the anti-PD-L1 inhibitor durvalumab (Imfinzi) demonstrated a 72% ORR in patients with relapsed, platinum-sensitive, BRCA-mutated ovarian cancer. So, this approach of combining of anti-PD-1/L1 immune agent with another PARP inhibitor may be suitable for you. Please discuss this option with your treating team.
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HelloitsB posted an update in the group The WeHeal Welcome Community
We support the right of every individual to choose whether or not to participate in vaccinations, free from threats and coercive strategies, and with informed consent as to the pros, cons, and current lack of scientific integrity supporting them. The Association of American Physicians and Surgeons agrees and has issued the following statement (link to their website) —
Statement on Federal Vaccine Mandates – AAPS | Association of American Physicians and SurgeonsTo: Oversight and Investigations Subcommittee, House Energy and Commerce Committee Senate Committee on Health, Education, Labor and Pensions Re: Statement federal vaccine mandates Feb. 26, 2019 The Association of American Physicians and Surgeons (AAPS) strongly opposes federal interference in medical decisions, including mandated vaccines. After being fully informed of the risks and benefits of a … -
NipperCat posted an update in the group The WeHeal Welcome Community
Important information for all of us to consider!
Is Sunscreen the New Margarine? | Outside OnlineCurrent guidelines for sun exposure are unhealthy and unscientific, controversial new research suggests—and quite possibly even racist. How did we get it so wrong? -
NipperCat posted an update in the group The WeHeal Welcome Community
“You can’t judge a book by its cover,” gets a new meaning — how you cook your well-selected foods is extremely vital to robust health. Quick and flashy does not necessarily equal healthy.
Microwaving your food is one of the most damaging things you can do to reduce nutrition – NaturalNews.comThere are probably worse ways to ruin the nutritional value of food and, indirectly, your health. But a Green Med Info article warned that there is no faster way to destroy the nutrients in your food than to pop it into a microwave oven.The days of cooking fresh, whole foods on the stove or in t
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Eric Drew posted an update in the group General Cancer Advocate Network
The 10 most common chemotherapy side effectsSide effects of chemotherapy include illness and infection, bleeding easily, hair loss, and nausea or vomiting. Learn more about 10 of the most common side effects, and how to combat them here. -
Polly joined the group Non-Hodgkin’s Lymphoma Advocate Network