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This is a recent treatment consultation we arranged for a stage 4 ovarian cancer patient. Bottom line, the latest most effective treatments seem to be a combination of immune therapy with a PARP inhibitor therapy. https://en.wikipedia.org/wiki/PARP_inhibitor – Get your free consultation on the WeHeal home page to find the most advanced treatments available for your case.

From your Caris reports, I see that your tumors are PD-L1 positive. It would make sense to try checkpoint immune inhibitors if you haven’t already had them.

Single-agent immunotherapy such as nivolumab (anti-PD-1) has demonstrated a modest response rate of 15% in PD-L1–positive platinum-resistant ovarian cancer. Recently, results of KEYNOTE-100 (NCT02674061) study showed that the overall response rate (ORR) with pembrolizumab (anti-PD-1) in patients with advanced recurrent ovarian cancer was 9% and was higher in patients with PD-L1 expression: 14% with a combined positive score ≥1 and 25% with a composite positive score of ≥10.

Since you also carry the BRCA1 mutation, it would also make sense to investigate PARP inhibitors in combination with immunotherapy. For example, Niraparib (a PARP inhibitor), has shown efficacy in patients with platinum-resistant/refractory ovarian cancer when in combination with pembrolizumab (anti-PD-1). Data from the recurrent ovarian cancer cohort of a recent trial showed an objective response rate of 25% in the 60 evaluable patients. The combination was also well-tolerated by patients. Please see: https://www.onclive.com/conference-coverage/sgo-2018/pembrolizumab-plus-niraparib-shows-promise-in-ovarian-cancer

Additionally, findings from the phase II MEDIOLA trial evaluating the combination of the PARP inhibitor olaparib and the anti-PD-L1 inhibitor durvalumab (Imfinzi) demonstrated a 72% ORR in patients with relapsed, platinum-sensitive, BRCA-mutated ovarian cancer. So, this approach of combining of anti-PD-1/L1 immune agent with another PARP inhibitor may be suitable for you. Please discuss this option with your treating team.

Important information for all of us to consider!

Is Sunscreen the New Margarine? | Outside Online

https://www.outsideonline.com/2380751/sunscreen-sun-exposure-skin-cancer-science

Current guidelines for sun exposure are unhealthy and unscientific, controversial new research suggests—and quite possibly even racist. How did we get it so wrong?

“You can’t judge a book by its cover,” gets a new meaning — how you cook your well-selected foods is extremely vital to robust health. Quick and flashy does not necessarily equal healthy.

Microwaving your food is one of the most damaging things you can do to reduce nutrition – NaturalNews.com

https://www.naturalnews.com/2018-12-10-microwaving-food-reduces-nutrition.html

There are probably worse ways to ruin the nutritional value of food and, indirectly, your health. But a Green Med Info article warned that there is no faster way to destroy the nutrients in your food than to pop it into a microwave oven.

The days of cooking fresh, whole foods on the stove or in t