Activity
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Katie posted an update in the group The WeHeal Welcome Community
For everyone looking for more affordable body scans, Radnet (www.radnet.com) and Inview Imaging (inviewimaging.com) are two good options. Best of luck!
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Eric Drew posted an update in the group Acute Myeloid Leukemia AML Advocate Network
Improved Survival With Integration of Chinese Herbal Medicine Therapy in Patients With Acute Myeloid Leukemia: A Nationwide Population-Based Cohort StudyIntegrative Cancer Therapies – Tom Fleischer, Tung-Ti Chang, Jen-Huai Chiang, Mao-Feng Sun, Hung-Rong Yen, 2017Purpose. Acute myeloid leukemia (AML) is the most deadly subtype of leukemia, and many patients with this disease seek other complementary therapies, one of whi… -
NipperCat posted an update in the group The WeHeal Welcome Community
Taking care of your eyes is very important for our well-being and safety!
Eye Health: Herbs and Remedies to Use for Natural Eye CareWhen asked about eye health, or natural eye care remedies. I’m happy to share that the best solutions are simple, and should be eaten or applied fresh. -
DocT posted an update in the group Acute Myeloid Leukemia AML Advocate Network
Hoping vitamin D (in high doses) will have an inhibitory effect on AML cell proliferation, as this 2013 article states, ” these data suggest that 25(OH) vitamin D3 exerts both direct anti-proliferative effects on leukemia cells and direct/indirect leukemia inhibitory microenvironment reprograming activities”
25(OH) Vitamin D3 Affects Acute Myeloid Leukemia Cell Proliferation | Blood JournalWe recently demonstrated that acute myeloid leukemia (AML) patients with insufficient serum 25(OH) vitamin D3 levels had a worse outcome following intensive induction therapy. However, the mechanisms by which 25(OH) vitamin D3 and its metabolites exert these effects are poorly understood. We utilized in vitro systems with orthogonal genomic and computational approaches to delineate leukemia-specific vitamin D molecular targets that may contribute to its activities. To achieve this goal, we systematically investigated vitamin D anti-proliferative effects using a genomically-annotated panel of human leukemia cell lines, including lines with genetic alterations that are commonly observed in patients. Since the genetic diversity of these cell lines reflects many of the alterations found in AML patients, we hypothesized that they collectively represent a model system to replicate candidate anti-leukemia drug effects. Specifically, we cultured 40 leukemia cell lines with and without 25(OH) vitamin D3 in a dose- and time-dependent manner for 72 hours and used high-throughput (HT) cell-based assays to simultaneously measure multiple modalities/ parameters related to cell proliferation and cytotoxicity (i.e. combining several HT assay chemistries to simultaneously assess cell number, viability, cytotoxicity and caspase activation events). Six AML cell lines (THP-1, MV4;11, MOLM-6, MOLM-13, EOL-1, JK-1) that responded to 25(OH) vitamin D3 treatment were identified and selected for multi-parametric RNA-Seq studies (NB 200nM Vitamin D treatment or vehicle control for 24 hours). Total RNA was extracted and analyzed by the Illumina HiSeq 2500 sequencing platform and mRNA, microRNA and ncRNAs were unambiguously quantitated. Utilizing gene expression profiles and in silico computational modeling of canonical or putative vitamin D receptor elements (VDRE) transcription factor promoter binding sites, we (1) identified a conserved/core gene transcriptional signature and (2) subsequently developed a vitamin D – genetic inference model. Gene enrichment analysis of the inferred network model identified genes involved in abnormal hematopoiesis, proliferation and differentiation, interleukin secretion, leukocyte migration, and bone marrow cell morphology and/or development. Notably, our data identified several 25(OH) vitamin D3 transcriptional regulatory cascades that converge on ETS2, JUND, NCOA4, RXR4, WT1, and ZFP30 transcription factors. Furthermore, we also demonstrate temporal and spatial regulation of protein kinases CAMK1 and FGFR, cytokine and growth factors (cAMP, CCL2, IL-8 and TNF), and cell differentiation markers (CD14, CD97, FCGR2A, IL3RG, IL7R, ITGAM, THBD). In summary, these data suggest that 25(OH) vitamin D3 exerts both direct anti-proliferative effects on leukemia cells and direct/indirect leukemia inhibitory microenvironment reprograming activities and better clarify the complex molecular mechanisms underlying the therapeutic activity of 25(OH) vitamin D3 in AML.Disclosures: No relevant conflicts of interest to declare.
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DocT joined the group Acute Myeloid Leukemia AML Advocate Network
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Eric Drew posted an update in the group Acute Myeloid Leukemia AML Advocate Network
Leukemia: Cancer cells killed off with diabetes drugResearchers find that boosting fat cells in the bone marrow using a diabetes drug not only kills off leukemic cells, but it also regenerates healthy ones. -
NipperCat posted an update in the group The WeHeal Welcome Community
It’s not only junk food that can cause problems…
Stress May Be Just As Bad For Your Body As Junk Food, Study FindsWe know that stress is bad for the brain, but now a new study finds that it also may be just as unhealthy for the body as a poor diet, especially in women. -
NipperCat posted an update in the group The WeHeal Welcome Community
Is there a “community” for blood pressure or high blood pressure?
Maintain a healthy weight to battle high blood pressure – Easy Health Options®It’s no secret that your blood pressure tends to go up as your age does. So how can you can keep your BP levels low and lower your risk for stroke and heart attack while you’re at it? Research shows these 5 factors will bring it down — but one stands out more than all the others combined… -
NipperCat posted an update in the group The WeHeal Welcome Community
Be aware of what you eat!!
Groundbreaking study reveals 20% of all deaths now caused by junk food and toxic food ingredients – NaturalNews.comHere I was, strolling up to a cancer fundraising event for a relative I hardly knew. I heard the sounds of drunken chatter and eyed the Budweiser banner sponsoring the event. A crowd of faces overflowed out of the banquet hall like fizz bubbling over the brim of a red solo cup. I entered through the -
NipperCat posted an update in the group The WeHeal Welcome Community
I love those blueberries, and look at all the benefits one gets when eating them!
If blueberries were pharmaceuticals, they would be hailed as the greatest “miracle” health breakthrough in the history of medicine – NaturalNews.comBlueberries are miraculous natural medicine. If they were prescription medications, they would be called a “miracle” health breakthrough and an unprecedented milestone in medical science. Yet you can get them without a prescription, without a visit to the doctor and without “permissio