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Daniel Christian Patient Advocate joined the group Ovarian Cancer Advocate Network
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Aarchi Advani joined the group Ovarian Cancer Advocate Network
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Louise joined the group Ovarian Cancer Advocate Network
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Bonnie Pedone joined the group Ovarian Cancer Advocate Network
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Andrea joined the group Ovarian Cancer Advocate Network
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Daniel Christian Patient Advocate joined the group Ovarian Cancer Advocate Network
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Daniel Christian Patient Advocate joined the group Ovarian Cancer Advocate Network
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Eric Drew posted an update in the group Ovarian Cancer Advocate Network
This is a recent treatment consultation we arranged for a stage 4 ovarian cancer patient. Bottom line, the latest most effective treatments seem to be a combination of immune therapy with a PARP inhibitor therapy. https://en.wikipedia.org/wiki/PARP_inhibitor – Get your free consultation on the WeHeal home page to find the most advanced treatments available for your case.
From your Caris reports, I see that your tumors are PD-L1 positive. It would make sense to try checkpoint immune inhibitors if you haven’t already had them.
Single-agent immunotherapy such as nivolumab (anti-PD-1) has demonstrated a modest response rate of 15% in PD-L1–positive platinum-resistant ovarian cancer. Recently, results of KEYNOTE-100 (NCT02674061) study showed that the overall response rate (ORR) with pembrolizumab (anti-PD-1) in patients with advanced recurrent ovarian cancer was 9% and was higher in patients with PD-L1 expression: 14% with a combined positive score ≥1 and 25% with a composite positive score of ≥10.
Since you also carry the BRCA1 mutation, it would also make sense to investigate PARP inhibitors in combination with immunotherapy. For example, Niraparib (a PARP inhibitor), has shown efficacy in patients with platinum-resistant/refractory ovarian cancer when in combination with pembrolizumab (anti-PD-1). Data from the recurrent ovarian cancer cohort of a recent trial showed an objective response rate of 25% in the 60 evaluable patients. The combination was also well-tolerated by patients. Please see: https://www.onclive.com/conference-coverage/sgo-2018/pembrolizumab-plus-niraparib-shows-promise-in-ovarian-cancer
Additionally, findings from the phase II MEDIOLA trial evaluating the combination of the PARP inhibitor olaparib and the anti-PD-L1 inhibitor durvalumab (Imfinzi) demonstrated a 72% ORR in patients with relapsed, platinum-sensitive, BRCA-mutated ovarian cancer. So, this approach of combining of anti-PD-1/L1 immune agent with another PARP inhibitor may be suitable for you. Please discuss this option with your treating team.
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llbruce posted an update in the group Ovarian Cancer Advocate Network
Dear Eric,
I’m a stage 3C ovarian cancer survivor. I heard your interview on the Healing Business podcast. While profoundly sad that you had to endure all the failed treatments and suffering that goes along with it, I am so thrilled by what you have done with this foundation. I am a yoga therapist by training and I used all my skills to build my team of healer. I survived the surgery, barely and the chemo, pretty well but it was my constant work with complementary healers and my own personal work that has left me cancer free. Since 2016 I have been an advocate for anyone who comes into my life with some kind of disease. I seek out different practitioners and work closely with my Naturopathic oncologist to provide resources and options for those who contact me. I love that this is a world wide program. I truly believe that the “crowd healing” mentality is what will save so many lives. But as I tell my students, its not enough to not want to die. You have to want to live and live well. So here’s to living a long and dedicated life, to making a difference and when it is our time to go leaving the world a better place. I am so happy to share this with my community through social media and word of mouth. If there is anyway to help you further this project please let me know. Lauri Bruce-
Lauri I just wanted to acknowledge your entry above and thank you so much for all of your healing work and spreading hope! Thank you! I also want to check on the progress of your cancer as we are working with some advanced treatment search technologies.. Please reach out to me if there is anything we can do to assist you in finding the optimal solution for your case.
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BTW Lauri there are many ways which people can help with the WeHeal project, simply by posting and sharing any important information here. I would also like to form an Ovarian Cancer advocate group and need help
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llbruce joined the group Ovarian Cancer Advocate Network
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DeAnn joined the group Ovarian Cancer Advocate Network
